Kratom is legal in the Czech Republic, but not regulated. A recent moral panic in the Czech media has threatened a ban on kratom in the country due to the ease of access of kratom for minors. Kratom is available online in Europe, sold as "not for human consumption". It is also available in vending machines in the Czech Republic, where people under 18 can easily access it.

“In the Czech Republic, thirty people die from drug overdoses and four hundred from alcohol every year. With kratom, there is no danger,” continued Vobořil. “The number of people who come to seek treatment for kratom addiction is also not large. Cases of unpleasant reactions, such as anxiety, are described, but these can also occur with caffeine or taurine, which are contained in energy drinks.”

Jakub Zientala, EKA coordinator, is in Prague lobbying for regulations. He notified Kratom Science of the proposal that kratom, as well as other substances such as cannabis mold and psilocybin, would be regulated in a new category called "psychomodular substances" that would not fall under EU food law, nor would it be regulated as a drug. If this new regulation and classification is successful, it could become a model for regulation not only in other EU member states, but also in the US, where kratom falls into the legal gray area between food, drug, and dietary supplement.

Three groups, the European Kratom Alliance (EKA), Czech-Slovak Kratom Association (CSKA), and the Pirate Party (progressive political party) are pushing for rational regulation of kratom in the Czech Republic.